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Current Affairs Science

It’s Burzynski, Jim, but not as we know it.

Stanislaw Burzynski has been in the spotlight for some time now, and if you’re reading this, there’s a good chance that you’re already aware of the controversy surrounding his alternative cancer treatment: Antineoplastons. Burzynski claims unheard of success rates with his treatment, and his website is full of testimonials from patients who say they have been cured of incurable cancers. Given all of the publicity, one might be convinced that Burzynski has just one string to his bow, but it seems that we may have been too quick to judge. Cancer patients can allegedly benefit from antineoplastons, but it seems that we can too.

Aminocare is the genetic solution to anti-ageing, brought to you by the Burzynski Clinic. It will solve all of our ageing problems with a whole new approach which focuses on genetics. As there are a whole host of problems associated with advanced age, many of them more significant than wrinkly skin, something which could combat these problems at a genetic level could be revolutionary – imagine a world free, not only of cancer, but of Alzheimer’s, for example.

Aminocare Brain Longevity Supplement is marketed as possibly preventative of Alzheimer’s (yours for the bargain price of $60 for 60 capsules!), and two of the ingredients stand out as significant. The first is curcumin, a compound which is part of the tumeric spice. Curcumin is the subject of ongoing trials because it has demonstrated some promising results in animal and in vitro studies, and it is true that in animal tests with transgenic Alzheimer mice, there a marked reduction in the plaques and inflammation which are characteristic of Alzheimer’s. So why aren’t we using this revolutionary treatment in humans? Simply, because we are not mice. Mice and humans absorb curcumin quite differently, resulting in drastically lowered amounts of free curcumin (that is, curcumin which has not bound to another molecule as part of metabolic processes) in humans. Curcumin which has bound to another molecule (most often glucuronic acid) can not pass through the blood brain barrier, and thus, cannot target the plaques and inflammation. Because we are aware that curcumin is absorbed differently, much research has been done on combining curcumin with other compounds, to try to increase the absorption. One such compound is found on the ingredients list: piperine.  A note in the product information tells us that piperine is something which increases the absorption of curcumin, and piperine was one of the first compounds tested which appeared to increase the bioavailability of curcumin. However, the overall levels of curcumin absorbed still do not match those seen in prior animal testing. There are some compounds which appear to be performing well in making curcumin absorb more readily, but those compounds are still in the early stages of testing, and piperine is not one of them. The inclusion of that animal test titbit in the product information is a subtle ploy; even though it is technically true, it is not the whole truth.

The second ingredient which caught my eye was “Glutamine Derivative (PG)”, which is described in the product information as a proprietary amino acid derivative phenylacetylglutamine. If you think that looks familiar, you’d be quite right – Burzynski says that it’s the active ingredient in A-10-I, one of his antineoplastons, which apparently cure Alzheimer’s as well as cancer.

Not content with ridding the world of cancer and degenerative  brain conditions, Burzynski also wants to tackle the scourge of make-up wearers everywhere – ageing. With Aminocare A10 Dietary Supplement, you can genetically slow down ageing. That’s powerful stuff (especially as there is still a ways to go before there is certainty about the genetic causes of ageing), let’s take a look at what’s in it. A10 Dietary Supplement claims to be a blend of amino acids, vitamin B12, and our old friend L-Glutamine Derivative (a.k.a. Dr. Burzynski’s proprietary ingredient, a.k.a. antineoplastons). Below are some of the claims made by this product, and I have highlighted some pertinent information:

A10 Supplement Claims

 

Absolutely none of the statements made about the efficacy of the product have been verified by an external body. This should be enough to make anyone very wary of spending money on such a product ($120 per box!), but if that’s not enough to give you pause for thought, a sidebar note about the product certainly should:

A10 Pic and Blurb

Aminocare A10 slows down the ageing process by gene expression modification. This is hinted at in the product description (“aids the regulation of normal cell division”) and is stated in the sidebar advertisement for the product (pictured left). This over-the-expensive-counter, completely untested, unregulated, and unverified capsule is going to stop you ageing by messing with your gene expression. How will it do this? Presumably, with the magic of antineoplastons, which are advertised as targeted gene therapy, because they “turn off” the “cancer genes”.

Perhaps you, like me, do not relish the thought of swallowing tablets. Never fear, as you may modify your gene expression and stay looking young simply by rubbing antineoplastons onto your skin.  The two antineoplaston ingredients in the  Aminocare Cream and Lotion cream “may restore the proper balance in gene expression” by turning off ageing genes, such as the icky wrinkly gene, and turning on other genes (such as the forever young gene) which are silenced during the normal ageing process. I have used chemicals in the lab which had the potential to mess with your genes and they are, in a word, scary. They are not something I would be in a hurry to smear all over my skin, so it is a very good thing that antineoplastons have an in-built identifier to know which are the “good” genes, and which are the “bad” genes.

A substance which claims to cure everything is called a panacea, and if you investigate this word, it’s likely that the only cures you’ll find are mythical ones, such as the philosopher’s stone, or the elixir of life, and this is not an accident. Throughout history, people have touted various substances as panaceas (tree sap, silver, mercury,etc.), and they have all been proven false. The truth is that we suffer from diseases which are so diverse that there is no one substance that could hope to conquer them all. The patter has changed, the terminology is littered with pseudo-scientific jargon, but the message is still the same. Come one, come all – you can inject them, eat them, or even just rub them all over your body. Antineoplastons are good for the soul!

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Science

Divining Intervention

Some quackery is obvious – there are posters, flashy ad campaigns, the works. Sometimes, though, it floats under the radar, waiting for someone to stumble upon it accidentally.

Today, I was trying to find some information on public water supply in Dublin. As you might expect, I turned to the official websites of the various councils and boards involved to try to find accurate information. One such website is the usually extremely useful Citizens Information site. This site is an Irish eGovernment initiative, and is maintained by the Citizens Information Board – in other words, it’s properly official. It’s the responsibility of the board to provide accurate and up-to-date information on all manner of public and social services available in Ireland (among other things).

As I tried to find the information I was looking for, I spotted some odd information under the Private Water Supplies section. I’ve quoted the section here:

If you are not part of a water supply scheme (capital or group), you will have to consider boring your own well and drawing out groundwater to supply your needs. One way of finding a suitable spot for a well to hire a water diviner to find out if there is groundwater beneath your land. However, even if a water diviner can tell you where to dig, he or she will not be able to tell you how deep you will have to drill or how much water you are likely to get. You can get this information from the Geological Survey of Ireland and it is usually free of charge.

Yes, that’s right. If you’d like to have your own connection to the groundwater, and want to know where you should put your well, the Citizens Information Board are happy to direct you to hire a water diviner. Water divination, for anyone who doesn’t know, is the process by which someone walks up and down with a y shaped stick, or “dowsing rod”, and when it points downwards, tells you that there is water present. If you think that this sounds ridiculous, and like it has absolutely no basis in modern science, you would be absolutely right. To date, water divining has not been shown to be any more effective than random chance. Indeed, prestigious scientific journal Nature puts dowsing in the category of “effects which until recently were claimed to be paranormal but which can now be explained from within orthodox science”, with dowsing effects being a result of the observer-expectancy effect and probability (i.e. random chance).

Worse still, a perfectly accurate and completely free resource, in the form of the Geographical Society of Ireland’s groundwater web map, is shunted to the bottom, and inexplicably recommended as something you might check after consulting a water diviner, but only to see how deep you might have to drill.

Honestly, I occasionally despair for the future of this country sometimes…